Peripheral
Artery Occlusive Disease (PAD) & Claudication
Treatment Options
Exercise for Claudication
Foot Care
Angioplasty & Stenting
Thrombolytic Therapy
Surgical Bypass
Amputation
Exercise for Claudication
Leg artery disease (peripheral arterial disease or PAD) can
cause discomfort or pain when you walk. The pain most often
occurs in the calf but can occur in your hips, buttocks,
thighs, knees, shins, or upper feet. This is called intermittent
claudication.
Claudication is discomfort or pain in your legs that happens
when you walk and goes away when you rest. You may not always
feel pain; instead you may feel a tightness, heaviness, cramping,
or weakness in your legs. Claudication often occurs more
quickly if you walk uphill or up a flight of stairs. Over
time, you may begin to feel claudication at shorter walking
distances.
What can I do to help claudication?
Your physician will give you a specific treatment plan for
your PAD, which may include lifestyle changes like quitting
smoking and losing weight. Your physician may also recommend
a walking program to help improve the blood flow to your
legs and decrease the pain you feel in your legs. Walking
programs can double or quadruple the distances you can walk
without pain.
Your vascular specialist will tailor your walking program
to you, but walking programs generally follow similar guidelines.
Your walking program will work best if you:
- Walk 3 or more times per week.
- Increase the amount of
time that you can walk without reproducing the pain in
your legs by gradually walking for longer and longer periods.
You will need to maintain the walking
program for 3 to 6 months to gain benefits from it.
Your physician will also tailor your walking program to your
specific needs, but typical sessions contain the following
elements:
- At first, walk until you feel mild leg pain, often about
3 to 5 minutes after starting.
- Continue walking until
the pain becomes moderate to severe (on a scale of 1 to
5, the pain is 3 or more).
- Stop and rest until the pain
goes away, usually after a few minutes.
- After the pain goes
away, begin walking again.
- Repeat this cycle of exercise
and rest for a total of 30 to 35 minutes
- As your program
continues, gradually increase the time you walk to a total
of 50 minutes to 1 hour.
As you progress in your walking program,
you will be able to walk for longer periods of time without
pain.
Foot Care
Foot care is important if you have leg artery disease
(peripheral arterial disease or PAD). In PAD, the blood
vessels in your limbs become blocked because of hardening
of the arteries. If you have PAD or diabetes, you must
pay special attention to your feet because diabetes makes
blood vessels more susceptible to hardening of the arteries
and nerve damage called neuropathy. Neuropathy can cause
loss of feeling, tingling, and pain in your feet or weakness
of your leg. Left untreated, nerve damage can lead to tissue
death, known as gangrene, and amputation.
If you have PAD or diabetes, it is important for you
to take care of your feet to make sure that they remain
healthy. You should monitor your feet regularly and protect
them from injuries through proper hygiene and injury prevention.
By taking care of your feet, you can avoid serious complications.
What can I do to prevent foot complications?
Your vascular specialist will give you a specific treatment
plan depending on your condition. This plan will include instructions
about how to take care of your feet. But it will be up to you
to make sure that they remain healthy, that you can detect
any problems early, and that you seek treatment right away.
Some of the ways in which you can keep your feet healthy include:
- Check your feet every day: Look for cuts, sores, blisters,
redness, warm spots, and swelling all around your feet and
ankles and between your toes. If you have trouble seeing
the soles of your feet, use a hand mirror or ask someone
to check them for you. If you find anything abnormal
when examining your feet, call your doctor
- Wash your
feet every day: Wash your feet in warm water, but don't
soak them because that can dry them out. Make sure the
water is not too hot by testing it first with your hand
or elbow. Dry your feet thoroughly including between
your toes.
- Moisturize your feet to keep the
skin soft and smooth: Apply a thin coating of a lotion such as Clean & Moist,
Uremol 10 & 20,
or Vitamin E ointment with Keri Lotion on your feet every
day to keep them smooth and to prevent dryness. Avoid using
lotion between your toes because this can cause infections
- Do
not treat yourself: If you develop rough skin, corns,
or calluses, ask your doctor to treat them, do not treat
them yourself.
- Trim your toenails regularly: Use a nail
trimmer to keep your toenails neat to avoid irritation
of the skin. Cut straight across the nail, avoid cutting
the corners of your nails, and smooth any rough spots
with an emery board or nail file. If you have trouble trimming
your toenails, ask someone to help you. If your toenails
become thick, yellowed, or are growing into your toes,
call your doctor.
- Always wear shoes and socks: To avoid
injuring your feet, always wear socks and shoes even
when you're inside. Socks that fit well, have some padding,
and are without a seam are best. Remember to check the
inside of your shoes to make sure nothing is in them
and that the linings are smooth. Also avoid wearing open-toe
or open-heel shoes.
- Buy shoes that fit properly: Shoes
that don't fit properly can cause blisters and sores.
Make sure to have your feet measured every time you buy
shoes, and pick shoes that match the shape of your feet.
Be sure that your shoes are snug enough so that your feet
don't slip in them, but leave enough room for you to wiggle
your toes. Buy rounded shoes and preferably low heels.
- Protect
feet from heat and cold: Always wear shoes on hot pavement.
If your feet are exposed to sunlight, remember to use
sunscreen. Avoid sitting or lying with your feet near radiators
or space heaters. Do not place heating pads or hot water
bottles on your feet. Wear socks to protect your feet from
cold. During cold weather, check your feet regularly during
cold weather to monitor for frostbite.
- Maintain blood
flow to your feet: Wiggle your toes and flex your feet
and ankles for 5 minutes 2 to 3 times each day. Remember
not to cross your legs for long periods of time. Avoid
tight-fitting socks and garters.
- Exercise: Exercise
improves circulation as well as overall health. Activities
like walking, dancing, swimming, and bicycling are all
activities that will improve your overall health but
minimize stress to your feet. Be sure to check with your
doctor before beginning an exercise program.
Angioplasty & Stenting (Endovascular
Treatment)
What is angioplasty and stenting?
In an angioplasty, your physician inflates a small balloon
inside a narrowed blood vessel. The balloon helps to widen
your blood vessel and restore normal blood flow. After widening
the vessel with angioplasty, your physician sometimes inserts
a stent depending upon the circumstances. Stents are tiny
mesh tubes that support your artery walls to keep your
vessels wide open.
Angioplasty and stenting is usually done through a small incision
or puncture in your skin, called the access site. Your physician
inserts a long, thin tube called a catheter through this access
site. Your physician guides the catheter through your blood
vessels to the blocked area. The tip of the catheter carries
the angioplasty balloon or stent.
Angioplasty most often is used to treat peripheral arterial
disease (PAD), which is another name for hardening of the arteries
not involving your heart. It can also be used, in some circumstances,
to treat narrowed areas in your veins.
Your arteries are normally smooth and unobstructed on the
inside, but as you age, plaque can build up in the walls of
your arteries. Cholesterol, calcium, and fibrous tissue make
up this plaque. As more plaque builds up, your arteries can
narrow and stiffen. This process is called atherosclerosis,
or hardening of the arteries. Eventually, enough plaque builds
up to reduce blood flow through your arteries.
Depending upon the particular circumstances, your physician
may recommend angioplasty as an alternative to bypass surgery,
which also treats narrowed arteries. For certain types of
blockages, angioplasty has some advantages when compared
to bypass surgery. For example, angioplasty does not require
a large incision. Because of this, angioplasty patients usually
spend less time in the hospital and recover at home faster
than bypass surgery patients. Also, your physician can usually
perform angioplasty while you are awake, whereas bypass surgery
requires general or regional anesthesia. Nevertheless, in
some circumstances, bypass surgery may be a better option.
Your physician will help you decide what alternative is best
for your particular situation.
How do I prepare?
First your physician asks you questions about your general
health, medical history, and symptoms. In addition, your
physician conducts a physical exam. Together these are known
as a patient history and exam. As part of your history and
exam, your physician will ask you if you smoke or have high
blood pressure. Your physician will also want to know when
your symptoms occur and how often.
Next, your physician will order tests to show how much plaque
has built up in your arteries. These tests can help your
physician determine whether you need an angioplasty. The
choice of test depends on the blood vessel in question and
not all of the tests need to be used for every situation.
These tests include:
- Duplex ultrasound
- Magnetic resonance angiography (MRA)
- Computed tomography
(CT) scan
If these tests show that your arteries
are moderately to severely narrowed, your physician may also
plan a test called conventional angiography that shows your
blood vessels on an x ray.
Your physician will give you the necessary instructions you
need to follow before the procedure, such as fasting. Usually,
your vascular surgeon will ask you not to eat or drink anything
8 hours before your procedure. Your physician will discuss
with you whether to reduce or stop any medications that might
increase your risk of bleeding or other complications. If
you have any allergies to contrast dye, which is used in
angiography, you should tell your physician at this time.
Since the contrast dye may contain iodine, you should also
let your physician know if you have allergies to iodine or
shellfish.
Immediately before your procedure, your physician may order
tests to check your blood's ability to clot and your kidney
function, and he or she may insert an IV to deliver fluids.
Angiography is usually performed again at the beginning of
the angioplasty procedure or sometimes the angioplasty procedure
is performed at the time of the initial angiogram.
Am I a candidate for angioplasty and stenting?
You are a candidate for angioplasty and stenting if you have
moderate to severe narrowing or blockage in one or more of
your blood vessels. Usually, you will also have symptoms
of artery disease, such as pain or ulceration, in one of
your limbs.
If you have extremely hard plaque deposits, blockages that
contain blood clots or a large amount of calcium, extensive
or particularly long blockages, or blood vessel spasms that
don't go away, you probably are not a good candidate for
angioplasty.
Am I at risk for complications during angioplasty and stenting?
Complications to angioplasty and stenting include reactions
to the contrast dye, bleeding or weakening of the artery
wall, re-blocking of the treated artery, and kidney problems.
Additionally, blockages can develop in the arteries downstream
from the plaque if plaque particles break free during the
angioplasty procedure.
If you have diabetes or kidney disease, you may have a
higher risk of complications from the contrast dye. In
the case of kidney disease, sometimes pre-treatment with
medications or fluids may decrease the impact on your kidneys.
People with blood clotting disorders also may have a higher
risk of complications from the procedure. If the plaque
deposits in your arteries are especially long, you may have
a greater chance of your artery closing up again after angioplasty
and stenting.
What happens during angioplasty and stenting?
Your physician will usually insert the angioplasty catheter
through a small puncture point over an artery in your groin,
your wrist, or your elbow. Before the insertion, he or she
will clean your skin and shave any hair. This reduces your
risk of infection. Your physician numbs your skin and then
makes a small cut to reach the artery below. Although you
may be given some mild sedation, your physician will usually
want you to stay reasonably alert to follow instructions
and describe your sensations during the procedure.
Your physician then inserts a guide wire or a guide catheter
into your artery. Using a type of x ray that projects
moving pictures on a screen, your physician guides the catheter
through your blood vessels. Because you have no nerve
endings in your arteries, you will not feel the catheters as
they move through your body.
Next, your physician will insert a balloon catheter over
the guide wire or through the guide catheter. The balloon
catheter carries a deflated and folded balloon on its tip.
Your physician guides the balloon catheter to the narrowed
section of your artery. He or she partially inflates the
balloon by sending fluid through the balloon catheter.
Your physician watches the x ray screen for signs of a pinch
in the balloon. Then, your physician will inflate the
balloon more, until the pinch caused by your artery flattens
out. When the balloon is full, your physician may deflate and
re-inflate it repeatedly to press the plaque against
your artery walls. Usually, this process takes a few minutes.
Sometimes, if you have a severe blockage, your physician
may need to inflate and deflate the balloon longer.
Your artery may stretch and your blood flow through the
artery stops when the balloon is pushing your artery open.
This may cause pain. However, any pain will go away when
your physician deflates the balloon and normal blood flow
resumes. Make sure to tell your physician if you experience
any symptoms during angioplasty.
There is a risk that your artery will re-narrow or become
blocked again at the site where the balloon was inflated. This
can happen soon after the procedure, or months to years later.
Re-narrowing of your artery is called restenosis, and if your
artery suddenly becomes blocked again it is called re-occlusion.
Restenosis can happen when scar tissue builds up inside your
arteries where the balloon compressed your plaque deposits.
After angioplasty, your physician will sometimes need to
use a stent to prevent restenosis and re-occlusion. A stent
is a tiny mesh tube that looks like a small spring, and comes
in a variety of sizes. To place a stent, your physician removes
the angioplasty balloon catheter and inserts a new catheter.
On this catheter, a closed stent surrounds a deflated balloon.
Your physician guides the stent through your blood vessels
to the place where the angioplasty balloon widened your artery.
Your physician inflates the balloon inside of the stent.
This expands the stent. Your physician then deflates and removes
the balloon. The stent remains in place to support the walls
of your artery. Your artery walls grow over the stent, preventing
it from moving. Although stents help prop open your arteries,
scar tissue can eventually form around stents and cause restenosis.
A new type of stent is coated with drugs. These drugs help
prevent scar tissue from forming inside a stent. Studies
have shown that these new stents are more likely to prevent
restenosis than ordinary, non-coated stents.
Once your physician finishes angioplasty and stenting, he
or she removes all of the catheters from your body. If blood-thinning
medications have been used, your physician may leave a short
tube, called a sheath, in your artery for a short time until
the medications have worn off sufficiently.
Eventually, your physician removes the sheath and presses
on the puncture area for 15 to 30 minutes to prevent bleeding.
Sometimes, instead of pressing, your physician may close
the area with a device that looks like a tiny cork or he
or she may give you stitches that will dissolve.
Angioplasty and stenting usually takes between 45 minutes
and 1.5 hours, but sometimes longer depending upon the particular
circumstances.
What can I expect after angioplasty and stenting?
Usually, you will stay in bed for 6 hours after your angioplasty.
During this time, your physician and the hospital staff closely
monitor you for any complications. If your physician inserted
the catheters through an artery in your groin, you may have
to hold your leg straight for several hours.
If you notice any unusual symptoms after your procedure,
you should tell your physician immediately. These symptoms
include leg pain that lingers or gets worse, a fever, shortness
of breath, an arm or a leg that turns blue or feels cold,
and problems around your access site, such as bleeding, swelling,
pain, or numbness.
After you return home, your physician will give you instructions
about everyday tasks. For example, you should not lift more
than about 10 pounds for the first few days after your procedure.
You should drink plenty of water for 2 days to help flush
the contrast dye out of your body. You can usually shower
24 hours after your procedure, but you should avoid baths
for a few days.
Your physician will prescribe aspirin or other medications
that thin your blood. These medications will help prevent
clots from forming on your stent. Your physician may also
ask you to follow an easy exercise program, like walking.
You will be asked to schedule a time to see your physician
after the procedure. At this appointment, your physician
may check your blood to make sure your medications are at the
right dosage. He or she may also take tests to see how blood
is flowing through your treated artery.
Are there any complications?
Serious complications are unusual following angioplasty and
stenting but, nevertheless, can occur.
Less serious complications include bleeding or bruising where
your physician inserted the catheters. Sometimes, the hole
created by the catheter does not completely close. This can
create a false channel of blood flow. Rarely, an abnormal
connection can form between an artery and a vein at the place
where the catheter was inserted. These problems usually go
away. However, if you have any serious symptoms, your physician
can treat you.
You may have an increased risk for blood clots forming along
your stent, especially in the first month after your procedure.
To reduce this risk, your physician may prescribe medications
that thin your blood.
As more time passes after your angioplasty and stenting,
restenosis becomes more likely. Stents, especially drug-coated
stents, may reduce this risk. However, in some cases, you
may need a repeat angioplasty or a bypass surgery.
Serious, but unusual complications include:
- Reaction to
contrast dye
- A clot in the artery that your physician treated
- A torn
or weakened blood vessel
- Kidney problems
- Blockages developing in arteries downstream
from the treated artery from particles of the plaque breaking
free (called cholesterol embolization).
Thromblytic Therapy
What is thrombolytic therapy?
Thrombolytic therapy is a treatment used to break up dangerous
clots inside your blood vessels. To perform this treatment,
your physician injects clot-dissolving medications into
a blood vessel. In some cases, the medications flow through
your bloodstream to the clot. In other cases, your physician
guides a long, thin tube called a catheter through your
blood vessels to the area of the clot. Depending on the circumstances,
the tip of the catheter may carry special attachments that
break up clots. The catheter then delivers medications
or mechanically breaks up the clot.
Thrombolytic therapy commonly
is used to treat an ischemic stroke, which is another name
for a clot in blood vessel in your brain. It can also be
used to treat clots in:
- A lung artery, called a pulmonary
embolism
- The deep veins of your leg, called deep vein
thrombosis (DVT)
- Your heart, which may cause a heart attack
- An artery elsewhere
in your body, such as in an arm or leg artery; or
- A bypass
graft or dialysis catheter that has become blocked
Your blood is normally a liquid that
travels smoothly through your arteries and veins. Sometimes,
however, blood components, called platelets, can form clumps
and other blood components can cause the blood to gel. This
process is called clotting or, more technically, coagulation.
This is a normal process that protects you from excessive bleeding
from even a minor injury. However, in certain circumstances
blood clots can build up inside a blood vessel and block blood
flow. At other times, pieces of these clots can break off,
travel through your bloodstream, lodge in a blood vessel somewhere
else in your body and obstruct normal blood flow. Blood clots
in your heart or lungs, for example, can starve the organ and
be life threatening.
Depending upon the situation, your physician
may decide to provide thrombolytic therapy, also called thrombolysis,
as an emergency treatment or as a scheduled procedure to dissolve
the blood clots. For example, you may receive emergency thrombolysis
if you are having a stroke. If you have DVT, your physician
may schedule thrombolytic therapy for you.
How do I prepare?
First your physician will ask questions about your general
health, medical history, and symptoms. In addition, your physician
will conduct a physical examination. Together these are known
as a patient history and exam. As part of your history and
exam, your physician will ask you to list any medications,
including vitamins or dietary supplements, you take. Your physician
will also want to know when your symptoms occur and how often.
Next, your physician will order tests to make sure that you
are able to receive thrombolysis safely. For example, he or
she will check to see if your blood is clotting properly and
that other factors, such as the mineral salts in your blood,
are normal. The tests you will receive depend on which blood
vessel is blocked and your medical condition. For example,
your physician may order an echocardiogram test to find out
whether there is a blood clot in your heart or an electrocardiogram
(ECG) to evaluate your heart rhythm.
Your physician will give you the necessary instructions you
need to follow before the thrombolysis procedure, such as fasting.
Usually, your physician will ask you not to eat or drink anything
12 hours before your procedure. Your physician will also discuss
with you whether to reduce or stop any medications that might
increase your risk of bleeding or other complications.
You will usually undergo a test called angiography either
before or as part of thrombolytic therapy. Angiography creates
a picture of your blood vessels (called an angoigram), and
uses a dye, called contrast, which is eventually flushed out
through your kidneys. If you have kidney trouble, or if you
have had a test that uses contrast before and had an allergic
reaction to the contrast, you should tell your vascular surgeon.
Am I a candidate for thrombolytic therapy?
You may be a candidate for thrombolytic therapy if you have
symptoms of a stroke, heart attack, pulmonary embolism, DVT,
or a clot in an artery or bypass graft in a limb. These symptoms
may include:
- Chest pain
- Numbness or tingling on one side of the body
- Blurred vision
in one eye
- Slurred speech
- Sudden weakness
- Severe swelling of an arm or leg; or
- Pain, numbness, or
coldness in a limb
If you have a life-threatening clot,
your physician will attempt to establish thrombolytic therapy
as soon as possible after symptoms begin, preferably within
1 to 2 hours.
If you have severe high blood pressure, active bleeding
or severe blood loss, a stroke from bleeding in the brain
(called hemorrhagic stroke), severe liver disease, or have
recently had surgery you probably are not a good candidate
for thrombolytic therapy.
Am I at risk for complications during thrombolytic therapy?
If you have diabetes or kidney disease, you may have a
higher risk of complications from the contrast agents
used in the angiogram. If you have kidney disease, sometimes
your physician can treat you with medications or
fluids before you receive contrast, to protect your kidneys
and minimize the risk.
People with blood clotting disorders also may have a
higher risk of complications from thrombolysis. Other
factors that may increase the risk for complications
include:
- History of internal bleeding
- Pregnancy
- Endocarditis, an infection in the lining of the
heart
- Advanced age
- Poorly controlled hypertension; or
- Diabetic retinopathy,
a problem in the eyes that results from diabetes
What happens during thrombolytic therapy?
In some hospitals, physicians perform thrombolytic
therapy in the intensive care unit, but in others thrombolysis
may be performed in nursing units familiar with the treatment
and potential complications. In either circumstance, your
physicians and nurses will carefully watch your vital signs
and be prepared for an emergency during the procedure,
such as bleeding. Initially, you will lie on an x-ray table,
and machines will monitor your vital signs.
Thrombolytic drugs can be delivered in two ways: through
a short catheter inserted in a vein (called an
intravenous, or IV, catheter), or through a long catheter that
is guided to the clot through your arteries or veins. In emergencies,
Physicians often choose the IV method because
it is quick and safe to perform outside of a hospital. If your physician
chooses to guide the catheter directly to the clot, the end
of the catheter may be placed in the vessels leading to your
brain, lung, heart, arm, or leg depending upon the location
of the clot.
To deliver the thrombolytic therapy, your physician
will make a small puncture over an artery or vein in
your groin, your wrist, or your elbow. This place is
called the access site. Before inserting the catheter
through this puncture, he or she will clean your skin
and shave any hair. This reduces your risk of infection.
Your physician then will numb your skin with a local
anesthetic and then sometimes makes a small cut or
puncture to reach the blood vessel below. Although
you may be given some mild sedation, you will usually
stay awake during the procedure.
Next, your physician will usually inject contrast through
the catheter to map your blood vessels with angiography
and to locate the clot. You may feel a warm sensation during
the injection, which is normal. As the contrast flows through
your blood vessels, x-rays are taken. The x-rays do not
pass through the contrast, so pictures of your blood vessels
appear on a screen. An indication of the clot location
will appear as well.
Once your physician locates the clot, depending on the
particular circumstances, he or she may inject the thrombolytic
drugs through an IV catheter. More commonly, your physician
will guide a longer catheter through your blood vessels
to the vicinity of the clot and then inject the drugs near
it. Because you have no nerve endings in your blood vessels,
you will not feel the catheters as they move through your
body.
Currently, the most common thrombolytic agents (“clot-busting" drugs)
are:
- Streptokinase
- Urokinase; and
- Tissue plasminogen activator (t-PA)
Other drugs include recombinant, or genetically engineered,
t-PA (a newer version of t-PA) and TNK (Tenecteplase.)
Your physician will periodically monitor the x-ray screen
to see the clot breaking up. However, depending on the size
and location of the clot, the drugs your physician chooses,
and other factors, this process can take several hours. Sometimes,
if you have a severe blockage, the treatment could last for
several days. Once the clot has been dissolved or if it cannot
be dissolved further, your physician will stop the medication.
When the tests used to monitor your blood's coagulation ability
are in a satisfactory range, your physician will then remove
the IV or catheter, and press on the access site for 10 to
20 minutes to stop any bleeding. During the process, and for
several hours afterwards, your physician will ask you to remain
still to minimize the risk of bleeding from the access site.
The technique for mechanical thrombectomy is similar, except
that small devices are attached to the catheter tip remove
the clot or even break it up physically. These devices include
a suction cup, a rotating device, and a high-speed fluid jet.
Mechanical thrombectomy can work faster than thrombolytic drugs
in some cases, and in favorable circumstances the procedure
may take as little as 30 minutes. You physician will advise
you if you are a good candidate for mechanical thrombectomy.
What can I expect after thrombolytic therapy?
Usually, you will stay in bed as you recover from thrombolytic
therapy. During this time, your physician and the hospital
staff closely watch you for any complications. You may receive
fluids, antibiotics, or painkillers. If your physician inserted
the catheter through an artery in your arm or leg, you may
have to hold the limb straight for several hours. Once any
bleeding from the access site stops, and your vital signs
are normal, you may be discharged. Often, however, you
will require further hospitalization for treatment of the
underlying reason for the clot, or for adjustment of anticoagulation
doses if needed to prevent clots from reforming.
If you notice any unusual symptoms after or during your
procedure, you should tell your physician immediately.
These symptoms may include:
- Arm or leg pain that lingers or gets worse
- A fever
- Shortness of breath
- An arm or a leg that turns blue, develops
swelling or feels cold; or
- Problems around your access site,
such as bleeding, swelling, pain, or numbness
Before your discharge, your physician
will give you instructions about everyday tasks to follow after
you return home. For example, you should not lift more than
about 10 pounds for the first few days after your procedure.
You should drink plenty of water for 2 days to help flush the
contrast dye out of your body. You can usually shower 24 hours
after your procedure, but you should avoid baths for a few
days.
During your recovery, you may experience nausea, vomiting,
or coughing. You should tell your physician if any nausea,
back pain or lightheadedness lingers, because these symptoms
could mean you have internal bleeding.
If you received thrombolytic therapy in an emergency, you
may receive additional care for your condition. For example,
if you had a stroke, your physician may prescribe medications,
a special diet, or physical therapy. If you had a heart
attack, your physician may need to examine your heart to
see if any other arteries are blocked. If you had an blocked
bypass graft, you may need further treatment or anticoagulation
to keep the bypass open.
Are there any complications?
Complications are not unusual with thrombolytic therapy,
which is why it should be carried out under close supervision.
However, your physician can manage most of them, including:
- Bleeding in the access site or elsewhere
- Low blood pressure;
or
- Allergy to thrombolytic drugs
Bleeding in the brain leading to stroke,
can also occur, but it is rare and affects fewer than 1 in
100 patients.
Thrombolytic therapy is not always successful.
In up to 25 percent of patients, the treatment is unable
to break up the clot. This is especially true if the clot has
been established for a long time. In another 12 out of every
100 patients, the clot or blockage will re-form in the blood
vessel, especially if an underlying reason for the clot to
form in the first place is not found and treated.
Surgical Bypass
What is surgical bypass?
Surgical bypass treats your narrowed arteries by creating
a bypass around a section of the artery that is blocked. Your
arteries are normally smooth and unobstructed on the inside
but they can become blocked through a process called atherosclerosis,
which means hardening of the arteries. As you age, a sticky
substance called plaque can build up in the walls of your
arteries. Cholesterol, calcium, and fibrous tissue make
up the plaque. As more plaque builds up, your arteries can
narrow and stiffen. Eventually, as the process progresses,
your blood vessels can no longer supply the oxygen demands
of your organs or muscles and symptoms may develop.
During a bypass, your vascular surgeon creates a new pathway
for blood flow using a graft. A graft is a portion of one
of your veins or a man-made synthetic tube that your surgeon
connects above and below a blockage to allow blood to pass
around it.
You may be familiar with bypass surgery on heart arteries,
but vascular surgeons also use bypasses to treat peripheral
arterial disease (PAD). Surgeons use bypasses most commonly
to treat leg artery disease, which is hardening of the arteries
in the leg. Surgeons also use bypass to treat arm artery
disease.
How do I prepare?
First your physician asks you questions about your general
health, medical history, and symptoms. In addition, your
physician conducts a physical exam and may order a blood
test to determine your cholesterol levels. Together, the
questions and examination are known as a patient history
and exam. Your physician will also want to know when your
symptoms occur and how often.
Next, your physician orders tests to locate the blockage
and choose the best places to connect the graft. These tests
include:
- Duplex ultrasound, which is a non-invasive test that uses
high-frequency sound waves to measure real-time blood flow
and detect blockages or other abnormalities in the structure
of your arteries
- Magnetic resonance angiography (MRA), which uses magnetic
fields and radio waves to show blockages inside your arteries
- Conventional Angiography, which produces x-ray pictures
of the blood vessels in your legs using a contrast dye
that is injected to highlight your arteries
If you have arm or leg artery disease,
your physician may order segmental blood pressures to determine
the narrowing of the arteries in your arm or leg. If you have
had a heart attack in the past, or if you have chest pain,
your physician might recommend a stress test or, possibly,
a heart catherization.
Your physician or vascular surgeon will
give you the necessary instructions you need to follow before
the surgery, such as fasting. Usually, your physician will
ask you not to eat or drink anything 8 hours before your
procedure. Your physician will discuss with you whether to
reduce or stop any medications that might increase your risk
of bleeding or other complications.
Am I a candidate for bypass surgery?
If you have symptoms of atherosclerosis, you may be a candidate
for bypass surgery. Symptoms can range from pain in the arms
or legs during activity, called intermittent claudication,
to the development of non-healing ulcers or gangrene (tissue
death) in more severe cases. You may be a candidate for bypass
surgery even if you are not eligible for angioplasty and
stenting.
Am I at risk for complications during procedure?
Factors that increase your chances of complications include:
- High blood pressure
- Obesity
- High cholesterol
- Coronary artery disease
- Chronic obstructive pulmonary disease,
such as emphysema
- Poor kidney function
- Diabetes
- Smoking
What happens during surgical bypass?
Your specific surgical procedure depends on your symptoms,
your overall physical condition, and how much
plaque has built up in your arteries. Your surgeon, with
the help of your anesthesiologist, may use either general
or regional (epidural or spinal) anesthesia for the procedure.
For an arm or leg bypass, your vascular surgeon usually
first selects and removes the vein that will serve as the
bypass graft for your artery. Your vascular surgeon usually
uses your great saphenous vein (GSV) for the graft, if
it is suitable. Your GSV runs under your skin between your
foot and your groin. Sometimes your surgeon may need to
use another vein or a synthetic fabric artery for the graft.
To reach the bypass site in your blocked artery, your surgeon
makes an incision in your skin over the artery.
Once your surgeon exposes the artery, he or she evaluates the
pulse in the healthy part of the artery. By checking the
pulse, your surgeon makes sure that the artery provides enough
blood flow to supply the bypass.
Your surgeon next opens the artery below the part
that is blocked. This is where he or she will connect
one end of the graft. Your surgeon sews the graft
into your artery with permanent stitches. Next your
surgeon routes the other end of the graft between
your muscles and tendons to a site above the blockage.
In the same way, the surgeon then opens the artery
and, at this location, stitches the graft onto this
end of the artery. Your surgeon checks the bypass
for correct alignment and leakage. During the procedure,
your vascular surgeon may perform an arteriogram or duplex
ultrasound examination in the operating room to check the
bypass for any problems. When the surgery is complete,
your surgeon closes all of the incisions. After the procedure,
your surgeon may order a duplex ultrasound or other non-invasive
tests, such as pulse volume recordings, to make sure the
bypass is functioning properly.
What can I expect after surgical bypass?
Your hospital stay may range from about 3 to 10 days. After
you leave the hospital, your surgeon will
remove staples or stitches from the incisions, usually about 7
to 14 days after your operation. You may need assistance from
a visiting nurse, home health aide, or physical therapist
when you first go home.
If you develop fevers, a cold painful arm or leg,
or if your incision area becomes extremely red, swells,
or begins draining, you should contact your physician
immediately.
If you have PAD, your physician or surgeon may recommend
that you take an antiplatelet medication, such
as aspirin, which can help prevent blood clots.
Are there any complications?
Complications from bypass surgery are possible, but
not usual. No procedure is risk-free, but you will
experience a minimum number of complications if you
select a well-trained vascular surgeon who specializes
in the type of bypass surgery that your symptoms indicate.
Some complications from bypass surgery are less serious
and may include swelling or inflammation at the incision
site. Others, such as blockage of the bypass, bleeding
from the incision or infection, are potentially more
serious. Your vascular surgeon will discuss the important
risks and benefits with you and answer your questions.
What can I do to stay healthy?
Surgical bypass does not stop plaque build up. If you have
bypass surgery, you should make
changes in your lifestyle to preserve the success of your
bypass graft. You should consider changes that will help
lower your blood pressure and decrease the chances that
plaque will affect your graft or other arteries. These
changes include:
- Eating foods low in fat, cholesterol, and calories
- Maintaining your ideal body weight
- Exercising aerobically,
such as brisk walking, for 20 to 30 minutes at least 5 times
each week
- Quitting smoking
Amputation
What is amputation?
In an amputation, a surgeon removes a limb, or part of a
limb, that is no longer useful to you and is causing you great
pain, or threatens your health because of extensive infection.
Most commonly, a surgeon removes your toe, foot, leg, or
arm. Physicians consider amputation a last resort.
The most common reason you may need an amputation is if you
have peripheral arterial disease (PAD) due to atherosclerosis
(hardening of the arteries). In PAD, the blood vessels in your
limbs become damaged because of hardening of the arteries or
diabetes. Your body's cells depend on a constant supply of
oxygen and nutrients from your blood. If your blood vessels
are unable to deliver blood and oxygen to your fingers or toes,
the cells and tissues die and are vulnerable to infection.
Extensive tissue death may require amputation.
How do I prepare?
Your physician will perform a physical examination to decide
whether you need an amputation. He or she will check you
for:
- Fever
- Cool skin near your wound
- Extremely painful skin
- Wound odor
- Infected or non-healing sores or wounds
Your physician will also order tests
to see how well blood is reaching your limbs. These tests include
angiography, duplex ultrasound, and blood pressure tests.
If you have any other conditions, such as diabetes, high
blood pressure, heart problems, poor kidney function, or infections,
your physician will discuss with you how to treat them. Your
physician will also test your physical strength, balance,
and coordination. If you are going to use an artificial limb,
your physician may measure you for the device before your operation.
This way, your artificial limb will be ready as soon as you
recover. You may receive counseling before your surgery to
help you adapt to the loss of your natural limb.
Your physician will discuss with you whether to reduce or
stop any medications that might increase your risk bleeding
or other complications. If you have any allergies to anesthesia,
pain medications, or antibiotics, you should tell your physician
at this time.
When do I need amputation?
Most people who require an amputation have PAD, a traumatic
injury, or cancer.
PAD is the leading cause of amputation in people age 50 and
older, and accounts for up to 90 percent of amputations overall.
Normally, surgeons treat advanced PAD through other methods,
like draining any infected tissue or performing surgery.
However, if these treatments do not work, amputation will
remove a source of major infection and may be necessary to
save your life.
A traumatic injury, such as a car accident or a severe burn,
can destroy blood vessels and cause tissue death. As a result,
infection can spread through your body and threaten your
life. Your medical team will make every effort to save your
limb by surgically replacing or repairing your damaged blood
vessels or using donor tissue. However, if these measures
do not work, amputation can save your life. Traumatic injuries
are the most common reason for amputations in people younger
than age 50.
Your physician may recommend amputation if you have cancerous
tumors in your limbs. You may also receive chemotherapy,
radiation, or other treatments to destroy cancer cells. These
treatments can shrink the tumor and increase the effectiveness
of your amputation.
Am I at risk for complications during amputation?
If you have other conditions, like diabetes or heart disease,
you have a higher risk of complications from an amputation.
Having a very serious traumatic injury also increases your
risk of complications. Above-the-knee amputations can be
riskier than below-the-knee amputations, because people who
receive above-the-knee amputations are more likely to be
in poor health.
What happens during amputation?
To perform an amputation, your physician must remove your
diseased limb but preserve as much healthy skin, blood vessel,
and nerve tissue as possible.
Choosing the incision site is important. If your surgeon
removes too little tissue, your wound will not heal because
unhealthy tissue remains. To determine how much tissue to
remove, your physician will check for a pulse at a joint
close to the site. He or she will also compare the skin temperatures
in the diseased limb with those in a healthy limb, and note
places where the skin appears red, since an incision made
through reddish skin may be less likely to heal. Your physician
will also check that your skin around the proposed incision
point still has sensitivity to touch. Finally, after he or
she makes the initial cut, your physician may decide that
more of your limb needs to be removed if the edges of your
skin do not bleed enough to allow them to heal.
Before the procedure begins, your anesthesiologist will put
you to sleep or numb your body below the spine. You will
be connected to machines that monitor your heart rate, blood
pressure, temperature, and brain function. Your surgeon then
cuts into your skin, leaving enough healthy skin to cover
your stump for better healing.
When your surgeon then cuts through the muscles, he or she
may either sew them to the bone, or shape them, to make sure
that your stump has a comfortable contour for your artificial
limb. Your surgeon also divides and protects your nerves,
so that they are not exposed and painful.
During your surgery, clamps are applied to minimize bleeding
when the surgeon divides the healthy major blood vessels. Before
finishing your amputation, your surgeon will stitch the vessels,
and then release the clamps to ensure that all bleeding points
are secure.
If you have a traumatic injury your surgeon will remove the
crushed bone. Your surgeon then will smooth the uneven areas
of your bone to prevent pain once you receive your artificial
limb. If necessary, your surgical team may then install temporary
drains that will drain your blood and other fluids.
When your surgeon has completely removed all of the dead
tissue, he or she may decide to leave the site open (open
flap amputation) or to close the flaps (closed amputation).
In an open flap amputation, your skin remains drawn back
from the amputation site for 10 to 14 days so your surgical
care team can clean off of any questionable or infected tissue.
Once the stump tissue is clean and free of infection, the
skin flaps are sewn together to close the wound. In a closed
amputation, the wound is sewn shut immediately. A closed
amputation is usually done if your surgeon is reasonably
certain that the chance of infection is small.
Your surgical care team may place a stocking over your stump
to hold drainage tubes and wound dressings, or your limb
may be placed in traction, or a splint, depending upon your
particular situation.
What can I expect after amputation?
After your surgery, you will stay in the hospital for approximately
5 to 14 days, depending upon your particular situation. Your
physician may teach you how to change your wound dressings,
or the hospital staff will change them for you. Your physician
usually checks the progress of your wound in about 7 to 10
days. Your physician will also monitor any conditions you
have that might slow your healing, such as hardening of the
arteries or diabetes. If you need pain medications or antibiotics,
your physician will prescribe them. Ideally, your wound should
fully heal in about 4 to 8 weeks after your surgery.
If your condition permits, ideally, you will receive physical
therapy soon after your surgery. Physical therapy includes
gentle stretching for the first 2 or 3 days. Later, you will
perform exercises, such as getting in and out of your bed
or in and out of your wheelchair. Eventually, you will learn
how to bear your weight on your remaining limb.
Depending upon your particular situation, you may also begin
to practice with your artificial limb as early as 10 to 14
days after your surgery, but this depends upon your comfort
and wound healing progress.
You may experience phantom pain (a sense of feeling pain
in your amputated limb) or other emotional concerns, such
as grief over the lost limb, after surgery. If this is the
case, your physician can recommend counseling or drug therapy,
as appropriate.
Are there any complications?
You may have complications following any surgical procedure.
Complications that occur specifically from amputation include
a joint deformity called contracture, a severe bruise called
a hematoma, death of the skin flaps (necrosis), wound opening,
or infection. Your surgeon or physician can treat all of
these complications. Rarely, you may need to undergo further
surgical treatment or another amputation.
What can I do to stay healthy?
If your wound has healed well and your artificial limb fits
you, your amputation should cause you no long-term medical
concerns. However, if you have PAD, amputation does not stop
plaque from building up. To prevent hardening of the arteries
from affecting other parts of your body, including your heart,
you should consider the following changes:
- Eat more foods low in saturated fat, cholesterol, and
calories
- Exercise regularly
- Maintain your ideal body weight
- Avoid smoking
You can learn how to adapt to having an artificial limb,
including getting regular exercise, with the help of
physical therapy. Studies have found that amputees who
engage in regular physical exercise feel better about
themselves than those who are more sedentary. Also, people
who recover from an amputation are more likely to have greater
job satisfaction, probably because of changes in their attitudes
regarding life goals.
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